Dissolving Microneedle Patch for Rabies DNA Vaccination in Dogs
نویسندگان
چکیده
J. Arya , Y-W. Chen , K. Dewitt , Y-W. Chiang , M. R. Prausnitz 1 1 Georgia Institute of Technology, 2 Merial Ltd. Purpose To stabilize rabies DNA vaccine in a dissolving microneedle patch and evaluate immunogenicity and dose sparing in dogs. Rabies is mainly a disease of animals, whereas humans get rabies primarily when they are bitten by dogs. Vaccinating domestic dogs and other animals has reduced rabies transmission to humans, however thousands of people in developing countries still die of rabies each year. Dissolving microneedle patches are a simple, sharps-free device that can enable mass vaccination of dogs.
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